6-氯-N,N-二甲基烟酰胺合成路线 （共 4 条）
反应条件
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 141 ;
反应条件
in tetrahydrofuran; dichloromethane T=0 - 20°C;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2258697 A1, 2010 ;
Location in patent: Page/Page column 72 ;
反应条件
in tetrahydrofuran; dichloromethane T=20°C; 96 h;
参考文献
WO2006/61193 A1, ;
Page/Page column 21 ;
WO 2006/061193 A1
反应条件
1: sodium azide / N,N-dimethyl-formamide / 60 h / 120 °C
2: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 17 h / 25 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BROTHERTON-PLEISS, Christine; JAIME-FIGUEROA, Saul; LOPEZ-TAPIA, Francisco Javier; LOU, Yan; OWENS, Timothy D.
Patent: WO2013/24078 A1, 2013 ;
