6-氯-N,N-二乙基-烟酰胺合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane
T=5°C; 1.25 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/71358 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
WO 2007/071358 A1
反应条件
sodium hydroxide; thionyl chloride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6297375 B1, 2001 ;
参考文献
Birman, Vladimir B.; Li, Ximin; Jiang, Hui; W. Uffman, Eric
Tetrahedron, 2006 , vol. 62, # 2-3 p. 285 - 294
反应条件
trichlorophosphate
T=110°C; 2 h;
参考文献
Yamanaka, Hiroshi; Araki, Tomio; Sakamoto, Takao
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, p. 2244 - 2247
反应条件
1: SOCl2; DMF / toluene / 1.5 h / 95 °C
2: tetrahydrofuran / 3.66 h / 0 - 60 °C
View Scheme
参考文献
Hoffmann-Emery, Fabienne; Hilpert, Hans; Scalone, Michelangelo; Waldmeier, Pius
Journal of Organic Chemistry, 2006 , vol. 71, # 5 p. 2000 - 2008
参考文献
Geigy A.G.
Patent: CH242949 , 1942 ;
反应条件
benzene
anschliessendes Erwaermen;
参考文献
Chem. Fabr. Tempelhof
Patent: DE817911 , 1951 ;
DRP/DRBP Org.Chem.
