1.1: s-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 °C 1.2: B(O-iPr)3 / tetrahydrofuran; hexane / -78 - 20 °C 1.3: 60 percent / hexane; ethyl acetate; tetrahydrofuran 2.1: 94 percent / Pd(PPh3)4; K3PO4 / dimethylformamide / 17 h / 80 °C 3.1: 71 percent / potassium tert-butylate / tetrahydrofuran / Heating View Scheme

1.1: s-butyllithium; TMEDA / tetrahydrofuran; hexane / 3 h / -78 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 75 percent / KOH / ethanol / 12 h / Heating View Scheme

tert.-butyl lithium in tetrahydrofuran; hexane T=-78°C; 3 h;

1: 100 percent / NaH / various solvent(s); tetrahydrofuran / 20 °C 2: 84 percent / tert-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C View Scheme

1: 100 percent / NaH / various solvent(s); tetrahydrofuran / 20 °C 2: 84 percent / tert-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C View Scheme