1-苄基-3-羟基氮杂环丁烷合成路线 （共 12 条）
反应条件
hydrogenchloride; sodium hydroxide in water 0.0833333 h; Ambient temperature;
参考文献
Higgins, Robert H.; Eaton, Quentin L.; Worth, Leroy; Peterson, Myra V.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 255 - 259
反应条件
sodium hydrogencarbonate in acetonitrile 7 h; Heating;
参考文献
Isoda, Takeshi; Yamamura, Itsuki; Tamai, Satoshi; Kumagai, Toshio; Nagao, Yoshimitsu
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 10 p. 1408 - 1411
反应条件
1: in water T=0 - 10°C; 18 h; 2: With sodium hydrogencarbonate in water; acetonitrile T=75°C; 10 - 16 h;
参考文献
WO2006/15194 A2, ;
Page/Page column 13 ;
反应条件
triethylamine in acetonitrile 24 h; Heating;
参考文献
Oh, Chang Ho; Rhim, Chul Yun; You, Choong Ho; Cho, Jin Rai
Synthetic Communications, 2003 , vol. 33, # 24 p. 4297 - 4302
反应条件
1: 71 percent / Et3N / acetonitrile / 48 h / Heating 2: 83 percent / TBAF*3H2O / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 8 p. 2703 - 2710
反应条件
1: 96 percent / hexane / 15 h / 20 °C 2: 89 percent / Et3N / CH2Cl2 / 3 h / 20 °C 3: 71 percent / Et3N / acetonitrile / 48 h / Heating 4: 83 percent / TBAF*3H2O / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 8 p. 2703 - 2710
反应条件
hydrogenchloride; triethylamine 1.) ethanol, reflux, 3 d; 2.) water, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 255 - 259
反应条件
hydrogenchloride in dichloromethane 0.5 h; Large scale reaction;
参考文献
Krishna Reddy; Udaykiran; Chintamani; Mahesh Reddy; Kameswararao, Ch.; Madhusudhan
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 462 - 466
反应条件
1: N-benzyl-3-hydroxyazetidine With formic acid; palladium 10 on activated carbon in methanol 20 h; 2: di-tert-butyl dicarbonate With triethylamine in methanol T=20°C; 24 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/50992 A1, 2006 ;
Location in patent: Page/Page column 34-35 ;
WO 2006/050992 A1
反应条件
1: With hydrogen; acetic acid; 5 palladium hydroxide on carbon in water T=55 - 65°C; P=2068.65 Torr; 2 - 8 h; 2: With hydrogenchloride T=5 - 40°C; 1.5 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2006/15194 A2, 2006 ;
Location in patent: Page/Page column 14 ;
