2-甲氧基-6-甲基苯甲醛合成路线 （共 15 条）
反应条件
1: hydroxylamine hydrochloride; triethylamine / 3 h / 80 °C 2: 1,1'-carbonyldiimidazole / dichloromethane / 15 h / 20 °C View Scheme
参考文献
RHIZEN PHARMACEUTICALS SA; NAGARATHNAM, Dhanapalan; VAKKALANKA, Swaroop Kumar, V.S.; MUTHUPPALANIAPPAN, Meyyappan; VISWANADHA, Srikant; BABU, Govindarajulu; BHAVAR, Prashant, Kashinath
Patent: WO2012/151525 A1, 2012 ;
WO 2012/151525 A1
Title/Abstract Full Text Show Details
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 0.5 h; HeatingIrradiation;
参考文献
Ghera, E.; Plemenitas, A.; Ben-David, Y.
Synthesis, 1984 , # 6 p. 504 - 506
反应条件
sodium chlorite; aminosulfonic acid in tetrahydrofuran; water 1 h; Ambient temperature;
参考文献
Hauser, Frank M.; Ellenberger, Suzanne R.
Synthesis, 1987 , # 8 p. 723 - 724
反应条件
dipotassium peroxodisulfate; copper(II) sulfate in water; acetonitrile
Heating;
参考文献
Bauer, Dennis M.; Rogge, Anita; Stolzer, Lukas; Barner-Kowollik, Christopher; Fruk, Ljiljana
Chemical Communications, 2013 , vol. 49, # 77 p. 8626 - 8628
反应条件
potassium carbonate in acetone
2 h; Reflux;
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
sodium hydrogencarbonate; silver nitrate; triethylamine
1.) DMSO, room temp, 1 h, 2.) 15 min; Yield given. Multistep reaction;
参考文献
Ghera, E.; Plemenitas, A.; Ben-David, Y.
Synthesis, 1984 , # 6 p. 504 - 506
反应条件
1: 2-iodo-5-methoxytoluene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran; hexane
T=0°C; Saturated solution;
参考文献
Mori, Keiji; Kawasaki, Taro; Sueoka, Shosaku; Akiyama, Takahiko
Organic Letters, 2010 , vol. 12, # 8 p. 1732 - 1735
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
Microwave irradiation;
2: With sodium hydrogencarbonate; silver nitrate; triethylamine in dimethyl sulfoxide
T=20°C; 1.5 h;
参考文献
Senthilmnrugan, Annamalai; Aidhen, Indrapal Singh
European Journal of Organic Chemistry, 2010 , # 3 p. 555 - 564
反应条件
1: 97 percent / DIBAL-H / hexane; diethyl ether / 0.17 h / -78 °C
2: 86 percent / MnO2 / benzene / 5 h / Heating
View Scheme
参考文献
Nakanishi, Tsutomu; Inatomi, Yuka; Murata, Hiroko; Iida, Naoki; Inada, Akira; Lang, Frank A; Murata, Jin
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1358 - 1361
反应条件
methanol; potassium hydroxide
T=120 - 140°C; im geschlossenen Rohr;
参考文献
Chuit; Bolsing
Bulletin de la Societe Chimique de France, 1906 , vol. <3> 35, p. 142
