1,2,3,4-四氢-6-甲氧基-2-甲基异喹啉合成路线 （共 19 条）
反应条件
hydrogenchloride; water T=180°C;
参考文献
Buck
Journal of the American Chemical Society, 1934 , vol. 56, p. 1769
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
2 h; Heating;
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
hydrogenchloride; water
参考文献
Buck
Journal of the American Chemical Society, 1934 , vol. 56, p. 1769
反应条件
1: dimethylformamide
2: p-TsOH*H2O / CH2Cl2
3: aq NaOH / dioxane
View Scheme
参考文献
Heinonen, Petri; Loennberg, Harri
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8569 - 8572
反应条件
1: p-TsOH*H2O / CH2Cl2
2: aq NaOH / dioxane
View Scheme
参考文献
Heinonen, Petri; Loennberg, Harri
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8569 - 8572
反应条件
1: aq NaOH / dioxane
View Scheme
参考文献
Heinonen, Petri; Loennberg, Harri
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8569 - 8572
反应条件
1: AcOH / ethanol / 18 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 90 percent / acetic anhydride / 1 h / 70 °C
4: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h
6: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 90 percent / acetic anhydride / 1 h / 70 °C
2: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h
4: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
5: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h
3: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
4: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
2: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
