1,2,3,4-四氢-6-甲氧基-2-甲基异喹啉合成路线 （共 19 条）
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h
2: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
3: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
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参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
formic acid
1) aq. ethanol, reflux, 8 h, pH=6, 2) heating; Yield given. Multistep reaction;
参考文献
Miller; Tsang
Tetrahedron Letters, 1988 , vol. 29, # 51 p. 6715 - 6718
反应条件
hydrogenchloride; zinc
参考文献
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
反应条件
1: benzene
2: zinc; concentrated hydrochloric acid
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参考文献
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
反应条件
1: phosphorus oxychloride / 0 °C / dann auf dem Wasserbad
2: benzene
3: zinc; concentrated hydrochloric acid
View Scheme
参考文献
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
反应条件
1: 175 °C
2: phosphorus oxychloride / 0 °C / dann auf dem Wasserbad
3: benzene
4: zinc; concentrated hydrochloric acid
View Scheme
参考文献
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
参考文献
Davies et al.
Journal of the Chemical Society, 1947 , p. 191,196
反应条件
Yield given. Multistep reaction;
参考文献
Heinonen, Petri; Loennberg, Harri
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8569 - 8572
参考文献
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
