4,5,6,7-四氢噻吩并[3.2-c]吡啶合成路线 （共 46 条）
反应条件
water; potassium hydroxide in toluene T=25 - 30°C;
参考文献
SANDOZ AG
Patent: WO2009/80469 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
triethylsilane; boron trifluoride diethyl etherate in dichloromethane T=-78°C; 2.5 h;
参考文献
Nguyen, Hai; Khatri, Hem Raj; Zhu, Jianglong
Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5464 - 5466
反应条件
sodium hydroxide; hydrogen bromide
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6498251 B1, 2002 ;
反应条件
hydrogenchloride in ethanol; water T=50°C; 6 h;
参考文献
WO2006/47302 A1, ;
Page/Page column 74 ;
WO 2006/047302 A1
反应条件
1: With hydrogenchloride; water T=75°C; 5 h; 2: With sodium hydroxide in water pH=7.5;
参考文献
WO2006/100502 A1, ;
Page/Page column 118 ;
反应条件
hydrogenchloride in tetrahydrofuran T=20°C; 1.5 h;
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1.1: CH2Cl2 / 0 - 20 °C 2.1: Et3N / CH2Cl2 / 0 - 20 °C 2.2: 435 mg / CH2Cl2 / 17 h / 20 °C 3.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 4.1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 5.1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 6.1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 7.1: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 2: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 3: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 4: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 5: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 2: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 3: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 4: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 2: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 3: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
