4,5,6,7-四氢噻吩并[3.2-c]吡啶合成路线 （共 46 条）
反应条件
1.1: 95 percent / MnO2 / CH2Cl2 / 48 h / 20 °C 2.1: CH2Cl2 / 0 - 20 °C 3.1: Et3N / CH2Cl2 / 0 - 20 °C 3.2: 435 mg / CH2Cl2 / 17 h / 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 5.1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 6.1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 7.1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 8.1: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
in hydrogenchloride; methanol; chloroform
参考文献
Elmore, Steven W.; Cooper, Curt S.; Schultz, Colleen C.; Hutchinson, Douglas K.; Donner, Pamela L.; Green, Brian E.; Anderson, David D.; Xie, Qinghua; Dinges, Jurgen; Lynch, Linda M.; Pratt, John K.
Patent: US2002/49223 A1, 2002 ;
US 20020049223 A1
反应条件
1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C 2: HCl / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
hydrogenchloride; water in ethanol 4 h; Inert atmosphereReflux;
参考文献
Kitabatake, Michikazu; Hashimoto, Aki; Saitoh, Toshiaki; Sano, Takehiro; Mohri, Kunihiko; Horiguchi, Yoshie
Heterocycles, 2010 , vol. 81, # 8 p. 1903 - 1921
反应条件
hydrogen bromide Heating;
参考文献
Kikuchi, Chika; Hiranuma, Toyokazu; Koyama, Masao
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2549 - 2552
反应条件
1: 95 percent / Et3N / CH2Cl2 / 18 h / 25 °C 2: tert-BuOK / toluene / 0.75 h / 75 °C 3: 2-methyl-propan-2-ol / 1 h / 40 °C 4: 1.) HCOOH, 2.) O3, CF3COOH, 3.) Me2S, 4.) H2S(g), HCl(g), TiCl4 View Scheme
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
参考文献
Sumita; Koumori; Ohno
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 8 p. 1676 - 1678
反应条件
1: tert-BuOK / toluene / 0.75 h / 75 °C 2: 2-methyl-propan-2-ol / 1 h / 40 °C 3: 1.) HCOOH, 2.) O3, CF3COOH, 3.) Me2S, 4.) H2S(g), HCl(g), TiCl4 View Scheme
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
反应条件
hydrogenchloride; hydrogen sulfide; titanium tetrachloride T=0 - 20°C; 24 h; Yield given;
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
反应条件
1: 56 percent / 8 molpercent RhCl(PPh3)3 / acetonitrile; H2O / 5 h / Heating 2: 1.) O3, CF3COOH, 2.) Me2S / 1.) CH2Cl2, CH3OH, -60 deg C, 2.) CH2Cl2, CH3OH, 0 deg C 3: H2S(g), HCl(g), TiCl4 / 24 h / 0 - 20 °C View Scheme
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
