4,5,6,7-四氢噻吩并[3.2-c]吡啶合成路线 （共 46 条）
反应条件
triethylamine in dichloromethane; water
参考文献
EGIS GYOGYSZERGYAR NYILANOSAN MKOeD RESZVENYTARSASAG; PORCS-MAKKAY, Marta; VOLK, Balazs; GREGOR, Tamas; BARKOCZY, Jozsef; MEZEI, Tibor; BRODA, Judit; NYULASI, Balint; RUZSICS, Gyoergy; MOLNAR, Enik; DEBRECZENI, Jozsef; NAGY, Kalman; PANDUR, Angela; SZENT-KIRALLYI, Zsuzsanna
Patent: WO2011/77174 A1, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=90°C; 4 h;
参考文献
Cogentus Pharmaceuticals, Inc
Patent: US2007/243243 A1, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
1.1: triethylamine; sodium iodide / tetrahydrofuran / 0 °C 1.2: 1.67 h 2.1: AlCl3, aluminium chloride / methanol / 23 h / 60 °C View Scheme
参考文献
Kaneka Corporation
Patent: EP2298729 A1, 2011 ;
反应条件
1.1: triethylamine / dichloromethane / 20 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / -40 - 10 °C / Inert atmosphere 2.2: -40 - 10 °C / Inert atmosphere 2.3: -40 - 20 °C / Inert atmosphere 3.1: tetrahydrofuran / 0 - 20 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice 5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 - 25 °C View Scheme
反应条件
1.1: triethylamine; sodium iodide / tetrahydrofuran / 0 °C 1.2: 1.67 h 2.1: AlCl3, aluminium chloride / methanol / 23 h / 60 °C 3.1: sulfuric acid / acetone / 12 h / 20 °C View Scheme
参考文献
Kaneka Corporation
Patent: EP2298729 A1, 2011 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C;
参考文献
WO2006/47302 A1, ;
Page/Page column 74 ;
WO 2006/047302 A1
反应条件
triethylamine in dichloromethane
反应条件
in hydrogenchloride; sodium hydroxide
参考文献
SANOFI
Patent: EP522956 A2, 1993 ;
反应条件
chloro-trimethyl-silane; triethylamine in toluene
参考文献
Sanofi
Patent: US4515951 A1, 1985 ;
反应条件
1: methyl (2-chlorophenyl)acetate With copper(ll) bromide in dimethyl sulfoxide
T=20°C; 0.166667 h;
2: 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine With oxygen in dimethyl sulfoxide
T=20°C; 24 h;
参考文献
Evans, Ryan W.; Zbieg, Jason R.; Zhu, Shaolin; Li, Wei; Macmillan, David W. C.
Journal of the American Chemical Society, 2013 , vol. 135, # 43 p. 16074 - 16077
