3-(苄氧基)-5-羟基苯甲酸甲酯合成路线 （共 18 条）
反应条件
potassium carbonate in acetone Benzylation; 5 h; Heating;
参考文献
Maekelae, Taru; Matikainen, Jorma; Waehaelae, Kristiina; Hase, Tapio
Tetrahedron, 2000 , vol. 56, # 13 p. 1873 - 1882
反应条件
1: 3,5-dihydroxybenzoic acid methyl ester With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 2: benzyl bromide in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7042 A1, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/007042 A1
反应条件
1: 3,5-dihydroxybenzoic acid methyl ester With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; Inert atmosphere; 2: benzyl bromide in N,N-dimethyl-formamide; mineral oil T=20°C; 2 h;
参考文献
THE UNIVERSITY OF SIDNEY; DUKE, Colin Charles; TRAN, Van Hoan; DUKE, Rujee Kyokajee
Patent: WO2012/149608 A1, 2012 ;
Location in patent: Page/Page column 34 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 25 h;
参考文献
Gunter, Maxwell J.; Johnston, Martin R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 8 p. 995 - 1008
反应条件
toluene-4-sulfonic acid in methanol
参考文献
Journal of Medicinal Chemistry, , vol. 18, p. 211 - 213
反应条件
1: K2CO3 / acetone 2: TsOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 18, p. 211 - 213
反应条件
1.1: acetyl chloride / 17 h / Reflux; Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere 2.2: 2 h / 20 °C View Scheme
反应条件
triphenylphosphine on polystyrene in tetrahydrofuran T=0°C; 0.5 h; polymer-supported triphenyl phosphine;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/80359 A1, 2005 ;
Location in patent: Page/Page column 73 ;
WO 2005/080359 A1
反应条件
triphenylphosphine on polystyrene; di-isopropyl azodicarboxylate in tetrahydrofuran 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/54200 A1, 2005 ;
Location in patent: Page/Page column 26-27 ;
WO 2005/054200 A1
反应条件
potassium carbonate in acetone
24 h; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2009/46802 A1, 2009 ;
Location in patent: Page/Page column 46-47 ;
WO 2009/046802 A1
