3-(苄氧基)-5-羟基苯甲酸甲酯合成路线 （共 18 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=120°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/121110 A1, 2005 ;
Location in patent: Page/Page column 90 ;
WO 2005/121110 A1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=5 - 10°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/17649 A1, 2007 ;
Location in patent: Page/Page column 59 ;
WO 2007/017649 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Kurata, Hitoshi; Suzuki, Sayaka; Ohhata, Yasuo; Ikeda, Takuya; Hasegawa, Toru; Kitayama, Ken; Inaba, Toshimori; Kono, Keita; Kohama, Takafumi
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1183 - 1186
反应条件
potassium carbonate in acetonitrile
Heating;
参考文献
Ohashi, Hiroshi; Ueno, Akihiro; Nakao, Toyoo; Ito, Junko; Kimura, Kaname; Ishikawa, Masaharu; Kawai, Hiroyuki; Iijima, Hiroshi; Osawa, Tatsushi
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1945 - 1948
反应条件
bis-(4-chlorophenyl)-sulphone; potassium carbonate
1) DMAc, toluene, reflux, 25 h; 2) DMAc, 160 deg C, 24 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gibson, Harry W.; Nagvekar, Devdatt S.; Xie, Donghang
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7503 - 7506
反应条件
potassium carbonate
1) DMAc, toluene, reflux, 25 h; 2) DMAc, 160 deg C, 24 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gibson, Harry W.; Nagvekar, Devdatt S.; Xie, Donghang
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7503 - 7506
反应条件
1: 96 percent / K2CO3 / acetonitrile / Heating
2: 96 percent / LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Ohashi, Hiroshi; Ueno, Akihiro; Nakao, Toyoo; Ito, Junko; Kimura, Kaname; Ishikawa, Masaharu; Kawai, Hiroyuki; Iijima, Hiroshi; Osawa, Tatsushi
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1945 - 1948
反应条件
1: 96 percent / K2CO3 / acetonitrile / Heating
2: 96 percent / LiAlH4 / tetrahydrofuran
3: 43 percent / NBS / CCl4
4: 82 percent / DEAD, PPh3 / tetrahydrofuran
5: 45 percent / n-BuLi / tetrahydrofuran / -78 °C
6: 54 percent / PDC / dimethylformamide
7: 81 percent / Bu4(NH4), KMnO4, pyridine / dimethylformamide
8: K2CO3 / dimethylformamide
9: 81 percent / Pd(OH)2/C, cyclohexene / ethanol / Heating
View Scheme
参考文献
Ohashi, Hiroshi; Ueno, Akihiro; Nakao, Toyoo; Ito, Junko; Kimura, Kaname; Ishikawa, Masaharu; Kawai, Hiroyuki; Iijima, Hiroshi; Osawa, Tatsushi
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1945 - 1948
