4-[(1,1-二甲基乙氧基)羰基]-2-氧代-1-哌嗪乙酸合成路线 （共 4 条）
反应条件
1: With water; sodium hydroxide in methanol 2.5 h; 2: in water pH=2; Acidic conditions;
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan; GRIMWOOD, Mike; ZHU, Yongbao; DING, Yanbing
Patent: WO2011/26241 A1, 2011 ;
Location in patent: Page/Page column 32-33 ;
WO 2011/026241 A1
反应条件
1: aq. HCl / 4 h / Heating 2: aq. Na2CO3 / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 4 p. 723 - 728
反应条件
sodium carbonate in 1,4-dioxane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 4 p. 723 - 728
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 - 65 °C / Inert atmosphere 1.2: 2.5 h / 20 - 65 °C 2.1: sodium hydroxide; water / methanol / 2.5 h 2.2: pH 2 / Acidic conditions View Scheme
参考文献
WO2011/26241 A1, ;
WO 2011/026241 A1
