N-[4-[(二甲基氨基)磺酰基]苯基]-乙酰胺合成路线 （共 7 条）
反应条件
water; potassium hydroxide in methanol T=65°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 71, p. 1 - 14
反应条件
in tetrahydrofuran; dichloromethane
T=20°C; 0.5 h;
参考文献
Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14
反应条件
trimethylamine in dichloromethane
1.) 33 deg C, 8 h, 2.) 40 deg C, 2 h; Further byproducts given;
参考文献
Stollen; Niclas; Zolch
Pharmazie, 1982 , vol. 37, # 10 p. 702 - 705
反应条件
1: acetic acid; sodium acetate / 0.5 h / 20 °C
2: 0.5 h / 60 °C
3: dichloromethane; tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14
反应条件
trimethylamine in dichloromethane
T=33 - 40°C; 10 h; further amines; MechanismProduct distribution;
参考文献
Stollen; Niclas; Zolch
Pharmazie, 1982 , vol. 37, # 10 p. 702 - 705
反应条件
1: 0.5 h / 60 °C
2: dichloromethane; tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14
参考文献
Itai; Yamamoto
Yakugaku Zasshi, 1938 , vol. 58, p. 683,684, 686
Chem.Abstr., 1940 , p. 86
