三环[8.2.1.03,8]十三-3,5,7-三烯-13-酮合成路线 （共 10 条）
反应条件
hydrogenchloride in water
参考文献
Belanger, Patrice Charles; Collins, Ian James; Hannam, Joanne Claire; Harrison, Timothy; Lewis, Stephen John; Madin, Andrew; McIver, Edward Giles; Nadin, Alan John; Neduvelil, Joseph George; Shearman, Mark Steven; Smith, Adrian Leonard; Sparey, Timothy Jason; Stevenson, Graeme Irvine; Teall, Martin Richard
Patent: US2004/29862 A1, 2004 ;
反应条件
N-ethyl-N,N-diisopropylamine
参考文献
Iddon, Brian; Redhouse, Alan D.; Yat, Patrick N.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 1083 - 1090
反应条件
1: 92 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.25 h / Heating
2: 92.7 percent / H2 / platinum oxide / acetic acid / 2.5 h / 1034.3 Torr
View Scheme
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
反应条件
lead(IV) acetate in trifluoroacetic acid
参考文献
Sparey, Tim; Beher, Dirk; Best, Jonathan; Biba, Mirlinda; Castro, Jose L.; Clarke, Earl; Hannam, Joanne; Harrison, Timothy; Lewis, Huw; Madin, Andrew; Shearman, Mark; Sohal, Bindi; Tsou, Nancy; Welch, Christopher; Wrigley, Jonathan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4212 - 4216
反应条件
hydrogenchloride; lead(IV) tetraacetate; triphenylphosphine in trifluoroacetic acid
参考文献
Merck and Co., Inc.
Patent: US4341904 A1, 1982 ;
反应条件
nitric acid
T=-35 - -20°C; 1.33333 h;
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
反应条件
1: 58 percent / nitric acid / 1.33 h / -35 - -20 °C
2: stannous chloride dihydrate, conc. HCl / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
反应条件
1: 1.) thallium trifluoroacetate, 2.) lead tetraacetate / 1.) TFA, RT, overnight, 2.) TFA, RT, 1 h, then reflux, 1 h
2: 83 percent / potassium carbonate / acetone / Ambient temperature
View Scheme
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
反应条件
1: 1.) thallium trifluoroacetate, 2.) lead tetraacetate / 1.) TFA, RT, overnight, 2.) TFA, RT, 1 h, then reflux, 1 h
2: 83 percent / potassium carbonate / acetone / Ambient temperature
3: 95 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.25 h / Heating
4: 97.6 percent / H2 / platinum oxide / acetic acid / 2.5 h / 1034.3 Torr
View Scheme
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
反应条件
1: 1.) thallium trifluoroacetate, 2.) lead tetraacetate / 1.) TFA, RT, overnight, 2.) TFA, RT, 1 h, then reflux, 1 h
2: 96 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.25 h / Heating
3: 94 percent / H2 / platinum oxide / acetic acid / 2.5 h / 1034.3 Torr
View Scheme
参考文献
Belanger, Patrice C.; Young, Robert N.; Scheigetz John; Dufresne, Claude; Springer, James P.
Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4329 - 4334
