5-溴-2-甲基-1-苯并呋喃合成路线 （共 5 条）
反应条件
boron tribromide in dichloromethane
T=-70 - 20°C; 1.75 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6348474 B1, 2002 ;
Location in patent: Page column 65 ;
反应条件
copper diacetate; lithium chloride; palladium dichloride in N,N-dimethyl-formamide
T=25°C; 0.5 h;
参考文献
Roshchin, Alexander I.; Kel'chevski, Sergey M.; Bumagin, Nikolai A.
Journal of Organometallic Chemistry, 1998 , vol. 560, # 1-2 p. 163 - 167
反应条件
1: CS2; bromine / 0 °C
2: alcoholic KOH-solution
View Scheme
参考文献
Adams; Rindfusz
Journal of the American Chemical Society, 1919 , vol. 41, p. 661
反应条件
1: K2CO3 / acetone / 18.5 h / 20 - 50 °C
2: aq. 8percent NaOH / methanol / 1 h
3: 1.) Ac2O, NaOAc, 2.) H2O / 1.) AcOH, reflux, 1 h, 2.) AcOH, reflux, 1 h
View Scheme
参考文献
Hongu, Mitsuya; Tanaka, Takashi; Funami, Nobuyuki; Saito, Kunio; Arakawa, Kenji; Matsumoto, Mamoru; Tsujihara, Kenji
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 22 - 33
反应条件
1: aq. 8percent NaOH / methanol / 1 h
2: 1.) Ac2O, NaOAc, 2.) H2O / 1.) AcOH, reflux, 1 h, 2.) AcOH, reflux, 1 h
View Scheme
参考文献
Hongu, Mitsuya; Tanaka, Takashi; Funami, Nobuyuki; Saito, Kunio; Arakawa, Kenji; Matsumoto, Mamoru; Tsujihara, Kenji
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 22 - 33
