1-碘-2-甲基-4-(三氟甲基)苯合成路线 (共 3 条)
反应条件
1: 2-methyl-4-trifluoromethylphenyl iodide With iodine; magnesium in tetrahydrofuran; dibromoethane, 1,2- T=-10°C; 15 h; Heating / reflux; 2: carbon dioxide in tetrahydrofuran; dibromoethane, 1,2- T=5°C; 3: With hydrogenchloride in tetrahydrofuran; dibromoethane, 1,2-; water
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93231 A2, 2003 ;
Location in patent: Page/Page column 106-107 ;
WO 03/093231 A2
反应条件
1: With sulfuric acid; sodium nitrite in ethanol; water
T=0°C; 1 h;
2: With sodium iodide in ethanol; water
T=0 - 20°C; 1.5 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/83781 A1, 2006 ;
Location in patent: Page/Page column 88 ;
WO 2006/083781 A1
反应条件
N-iodo-succinimide
T=0 - 20°C; 0.333333 h;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93231 A2, 2003 ;
Location in patent: Page/Page column 106 ;
WO 03/093231 A2