6-氯-1,3-二氢-1-苯基-2H-苯并咪唑-2-酮合成路线 （共 10 条）
反应条件
sodium ethanolate in ethanol
3 h; Heating;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
tri-ruthenium(0)dodecacarbonyl; sodium chloride in acetonitrile
T=220°C; P=37503 Torr; 2 h;
参考文献
Pizzotti, Maddalena; Cenini, Sergio; Quici, Silvio; Tollari, Stefano
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 4 p. 913 - 918
反应条件
1: 86 percent / CHCl3 / 20 h / Heating
2: 99.3 percent / EtONa / ethanol / 3 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
potassium carbonate in methanol
T=50 - 55°C; 12 h;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
sodium hydroxide in methanol
5 h; Heating;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
potassium carbonate in methanol
T=50 - 55°C; 12 h;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
sodium hydride
1.) DMF, 60 - 70 deg C, 30 min; 2.) DMF, 60 - 70 deg C, 10 h; Yield given. Multistep reaction;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 34 percent / NaOH / methanol / 5 h / Heating
2: 73 percent / 2 N aq. NaOH / ethanol / 0.5 h / 50 °C
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 57 percent / NaOH / methanol / 10 h / Ambient temperature
2: 81 percent / H2S / pyridine; triethylamine / 3 h
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
反应条件
1: 82 percent / K2CO3 / methanol / 12 h / 50 - 55 °C
2: 38.5 percent / P2S5 / xylene / 8 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 321 - 326
