5-氯-1,3-二甲基-1H-吡唑-4-甲醛合成路线 （共 13 条）
反应条件
bis(trichloromethyl) carbonate in chlorobenzene
T=130°C; Vilsmeier formylation; 5 h;
参考文献
Panda; Karmakar; Jena
Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 12 p. 1500 - 1508
反应条件
in N-methyl-acetamide
参考文献
Byk-Gulden Lomberg Chemische Fabrik GmbH
Patent: US3974176 A1, 1976 ;
反应条件
trichlorophosphate in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
参考文献
El-Shekeil, Ali; Babaqi, Abdulla; Hassan, Mohammed; Shiba, Sayed
Acta Chimica Hungarica, 1989 , vol. 126, # 6 p. 813 - 820
反应条件
trichlorophosphate
T=50 - 60°C; Vilsmeier-Haack reaction;
参考文献
Rani, Archna; Jain, Sapna; Dureja, Prem; Kumar, Rita; Kumar, Anil
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 10 p. 1524 - 1531
反应条件
1: H2SO4 / ethanol / 17 h / Heating
2: POCl3 / 12 h / 80 °C
View Scheme
参考文献
Gilbert, Adam M.; Bursavich, Matthew G.; Lombardi, Sabrina; Georgiadis, Katy E.; Reifenberg, Erica; Flannery, Carl R.; Morris, Elisabeth A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1189 - 1192
反应条件
aluminium trichloride in benzene
T=25°C; 24 h;
参考文献
El-Shekeil, Ali; Babaqi, Abdulla; Hassan, Mohammed; Shiba, Sayed
Acta Chimica Hungarica, 1989 , vol. 126, # 6 p. 813 - 820
反应条件
aluminium trichloride in benzene
T=25°C; 24 h;
参考文献
El-Shekeil, Ali; Babaqi, Abdulla; Hassan, Mohammed; Shiba, Sayed
Acta Chimica Hungarica, 1989 , vol. 126, # 6 p. 813 - 820
反应条件
trichlorophosphate
T=80°C; 12 h;
参考文献
Gilbert, Adam M.; Bursavich, Matthew G.; Lombardi, Sabrina; Georgiadis, Katy E.; Reifenberg, Erica; Flannery, Carl R.; Morris, Elisabeth A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1189 - 1192
反应条件
1: ethanol
2: trichlorophosphate / 50 - 60 °C
View Scheme
参考文献
Rani, Archna; Jain, Sapna; Dureja, Prem; Kumar, Rita; Kumar, Anil
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 10 p. 1524 - 1531
反应条件
1: ethanol
2: trichlorophosphate / 50 - 60 °C
View Scheme
参考文献
Rani, Archna; Jain, Sapna; Dureja, Prem; Kumar, Rita; Kumar, Anil
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 10 p. 1524 - 1531
