2-(4-甲氧苯基)乙胺合成路线 （共 112 条）
反应条件
1: 88.4 percent / CH2Cl2 / 1.5 h / Ambient temperature
2: 84.5 percent / HNO3, TFA / 2 h / Ambient temperature
View Scheme
参考文献
Huffman; Hall; Grant; Wilson; Hieble; Hahn
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 933 - 935
参考文献
Phillips
Journal of the American Chemical Society, 1950 , vol. 72, p. 3298
反应条件
1: 91 percent
2: 70 percent / NaBH4 / 10percent Pd/C
3: 73 percent
View Scheme
参考文献
Baraldi; Vicentini; Simoni; Guarneri
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 6 p. 369 - 375
反应条件
triethylamine in diethyl ether
1 h; Ambient temperature;
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
triethylamine in tetrahydrofuran
24 h; Ambient temperature;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
FeCl3·6H2O; sulfur in neat (no solvent)
T=120°C; 24 h; Inert atmosphere;
参考文献
Nguyen, Thanh Binh; Retailleau, Pascal; Al-Mourabit, Ali
Organic Letters, 2013 , vol. 15, # 20 p. 5238 - 5241
反应条件
2: DDQ
3: 250 °C
4: 35 percent / LDA / tetrahydrofuran / 0 °C
View Scheme
参考文献
Estevez; Guitian; Villaverde; Castedo
Tetrahedron Letters, 1989 , vol. 30, # 42 p. 5785 - 5786
参考文献
Boyce, Rustum; Chu, Daniel
Patent: US2005/124652 A1, 2005 ;
US 20050124652 A1
反应条件
in tetrahydrofuran
robotic synthesis; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Linclau, Bruno; Sing, Ashvani K.; Curran, Dennis P.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2835 - 2842
反应条件
1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 25 °C
2: boron tribromide / dichloromethane / 4 h / 0 - 20 °C
View Scheme
参考文献
Kurouchi, Hiroaki; Kawamoto, Kyoko; Sugimoto, Hiromichi; Nakamura, Satoshi; Otani, Yuko; Ohwada, Tomohiko
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9313 - 9328,16
