2-(4-甲氧苯基)乙胺合成路线 （共 112 条）
参考文献
Barger; Walpole
Journal of the Chemical Society, 1909 , vol. 95, p. 1722
参考文献
Rosenmund
Chemische Berichte, 1909 , vol. 42, p. 4782
反应条件
1: KOH / H2O / 0 deg C to r.t. 2: H2O / 0 °C 3: KOH / H2O / Ambient temperature View Scheme
参考文献
Hirashima, Akinori; Yoshii, Yutaka; Eto, Morifusa
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 7 p. 1062 - 1065
反应条件
1: sodium acetate 2: sodium; xylene / Behandeln der Reaktionsloesung mit Methyljodid 3: hydriodic acid 4: concentrated hydrochloric acid / 170 °C 5: methanol View Scheme
参考文献
Walpole
Journal of the Chemical Society, 1910 , vol. 97, p. 946
反应条件
ethanol; nickel T=200 - 240°C; Hydrogenation;
参考文献
Metayer
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 242
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1948 , vol. 226, p. 500
反应条件
2: POCl3 / 1,2,3,4-tetrahydro-naphthalene View Scheme
参考文献
Augelli-Szafran, Corinne E.; Jaen, Juan C.; Moreland, David W.; Nelson, Carrie B.; Penvose-Yi, Jan R.; Schwarz, Roy D.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1991 - 1996
反应条件
1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 2-(4-methoxy-phenyl)ethylamine in dichloromethane T=20°C; 4 h; 2: (carboxymethyl)trimethylammonium chloride hydrazide in methanol; dichloromethane
参考文献
ACS Combinatorial Science, , vol. 15, # 4 p. 208 - 215
反应条件
1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2005/44191 A2, 2005 ;
Location in patent: Figure 12 ;
反应条件
hydrogenchloride in water 1.33333 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/99786 A2, 2003 ;
Location in patent: Page 35 ;
反应条件
1: 94.3 percent / H2SO4 / 2 h / Heating 2: 76.1 percent / toluene / 0 °C View Scheme
参考文献
Lebedev; Lebedeva; Sheludyakov; Ovcharuk; Kovaleva; Ustinova
Russian Journal of General Chemistry, 2006 , vol. 76, # 3 p. 469 - 477
