2-(4-甲氧苯基)乙胺合成路线 （共 112 条）
反应条件
carbon in ethyl acetate 5 h; Heating;
参考文献
Lazewska; Kiec-Kononowicz, Katarzyna; Pertz; Elz; Stark; Schunack
Pharmazie, 2002 , vol. 57, # 12 p. 791 - 795
反应条件
in toluene T=100°C; Cooling with ice;
参考文献
Wang, Liutang; Zhang, Bin; Ji, Jianxin; Li, Bogang; Yan, Jufang; Zhang, Weiyu; Wu, Yong; Wang, Xuechao; Hou, Hui
Synthetic Communications, 2010 , vol. 40, # 1 p. 52 - 57
反应条件
potassium hydroxide T=100°C; filtriert das entstand.Hordenin-methylaether-jodmethylat ab,entfernt aus dem Filtrat die primaere und sekundere Base durch Acetylieren mit Essigsaeureanhydrid und koht den so erhalt.Hordenin-methylaether mit Jodwasserstoffsaeure;
参考文献
Rosenmund
Chemische Berichte, 1910 , vol. 43, p. 311
反应条件
sodium acetate; acetic anhydride; acetic acid
参考文献
DowElanco
Patent: US5137879 A1, 1992 ;
反应条件
1: Et3N / tetrahydrofuran 2: PPA / 140 °C 3: LAH / tetrahydrofuran View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang
Patent: WO2012/97682 A1, 2012 ;
反应条件
2: aqueous HCl; ethanol View Scheme
参考文献
Cannon et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 1323,1325
参考文献
Wang, Kan; Herdtweck, Eberhardt; Doemling, Alexander
ACS Combinatorial Science, 2012 , vol. 14, # 5 p. 316 - 322
反应条件
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate
参考文献
Wang, Zhaolin; Fraley, Cara; Mezo, Adam R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1253 - 1256
反应条件
TEA; trichloroisocyanuric acid in N,N-dimethyl-formamide T=15°C; 4 h;
参考文献
Synlett, , # 12 p. 2180 - 2184
反应条件
sodium hydroxide in diethyl ether Ambient temperature;
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
