2-(4-甲氧苯基)乙胺合成路线 （共 112 条）
参考文献
Holbein; Perrot
Ann.scient.Univ.Besancon <2> Chimie, 1956 , # 2 p. 13,20
反应条件
bromine in acetic acid 48 h; Ambient temperature;
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
反应条件
NiCl2(phenyldi(cyclohexyl)phosphine)2 in diethyl ether T=23°C; 15 h;
参考文献
Dankwardt, John W.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 18 p. 2428 - 2432
反应条件
hydrogenchloride in water 14 h; Reflux;
参考文献
Lacotte, Pierre; Puente, Celine; Ambroise, Yves
ChemMedChem, 2013 , vol. 8, # 1 p. 104 - 111
反应条件
in water; acetic acid T=20 - 55°C;
参考文献
Cheng, Xian-Chao; Sun, Su-Xia; Zhang, Hao; Dong, Wei-Li; Liu, Gui-You; Wang, Run-Ling; Xu, Wei-Ren
Asian Journal of Chemistry, 2011 , vol. 23, # 9 p. 4114 - 4116
反应条件
2: 1.) base, 2.) O-(2,4-dinitrophenyl)hydroxylamine 3: 86 percent / NBS / tetrahydrofuran / 16 h / Ambient temperature; Irradiation View Scheme
参考文献
Collazo, Luis R.; Guziec, Frank S.; Hu, Wei-Xiao Jr.; Pankayatselvan, Ratnadevi
Tetrahedron Letters, 1994 , vol. 35, # 43 p. 7911 - 7914
反应条件
potassium carbonate in dichloromethane Ambient temperature;
参考文献
Vecchietti; Clarke; Colle; Dondio; Giardina; Petrone; Sbacchi
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2970 - 2978
反应条件
1: 2-(4-methoxy-phenyl)ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride in acetic acid; N,N-dimethyl-formamide T=20°C; Solid phase reaction; reductive amination; 69 h; 2: chloroacetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide T=20°C; Solid phase reaction; acylation; 15 h; 3: With dimethylsulfide; water; trifluoroacetic acid in dichloromethane T=20°C; Solid phase reaction; cleavage of amide; 15 h;
参考文献
Pegurier, C.Ecile; Curtet, Sophie; Nicolas, Jean-Paul; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Langlois, Michel
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 163 - 171
反应条件
potassium carbonate in tetrahydrofuran T=25°C;
参考文献
Xu, Wei; Zhang, Xiao-Ming; Mariano, Patrick S.
Journal of the American Chemical Society, 1991 , vol. 113, # 23 p. 8863 - 8878
反应条件
ethanol; nickel T=200 - 240°C; Hydrogenation;
参考文献
Metayer
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 242
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1948 , vol. 226, p. 500
