氮芥盐酸盐合成路线

参考文献

Chem. Fabr. Promonta
Patent: GB901187 , 1958 ;

参考文献

Ong; Profitt; Fortunato; Glamkowski; Ellis; Geyer; Wilker; Burghard
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 981 - 986

55-86-7氮芥盐酸盐

105-59-9甲基二乙醇胺+

111068-26-9

参考文献

Golding, Bernard T.; Kebbell, Michael J.; Lockhart, Ian M.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 705 - 714

7732-18-5水+

55-86-7氮芥盐酸盐

105-59-9甲基二乙醇胺

参考文献

Price; Pohland; Velzen
Journal of Organic Chemistry, 1947 , vol. 12, p. 311
Full Text Show Details
Golumbic; Fruton; Bergmann
Journal of Organic Chemistry, 1946 , vol. 11, p. 531,585

926-64-7(二甲氨基)乙腈+

55-86-7氮芥盐酸盐

104-19-8N,N,4-三甲基哌嗪-1-乙胺

参考文献

Chem.Fabr.Promonta
Patent: GB901197 , 1958 ;

55-86-7氮芥盐酸盐+

140-29-4氰化苄

3627-62-14-氰基-1-甲基-4-苯基哌啶

参考文献

NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/71035 A1, 2007 ;
Location in patent: Page/Page column 26 ;
WO 2007/071035 A1

55-86-7氮芥盐酸盐+

99-09-2间硝基苯胺

110-85-0哌嗪+

148546-97-81-甲基-4-(3-硝基苯基)哌嗪

参考文献

Merck Sharp and Dohme, Ltd.
Patent: US5618812 A1, 1997 ;

143-33-9氰化钠+

55-86-7氮芥盐酸盐

1555-58-43,3'-甲基亚胺-二-丙腈

参考文献

Golding, Bernard T.; Kebbell, Michael J.; Lockhart, Ian M.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 705 - 714

参考文献

Crane et al.
Journal of the Chemical Society, 1946 , p. 827,829

326-62-52-氟苯基乙腈+

55-86-7氮芥盐酸盐

171-75-5螺[吲哚啉-3,4-哌啶]

参考文献

Bristol-Myers Squibb Company
Patent: US2006/293281 A1, 2006 ;
Location in patent: Page/Page column 73 ;
US 20060293281 A1