反应条件
1: 5-bromo-1,3-dihydro-2H-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride in tetrahydrofuran
T=-78 - 20°C; 48.5 h;
参考文献
Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Jin, Hong; Zhu, Zhengguang; Wan, Shanhe; Zhang, Junyan; Yu, Pengjiu; Zhang, Jiajie; Wu, Shuguang
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 370 - 375