1-甲基-9H-芴-9-酮合成路线 （共 38 条）
反应条件
hydrogenchloride; sodium nitrite
1.) 0 deg C, 2.) reflux, 2.5 h;
参考文献
Tomioka, Hideo; Kawasaki, Hiroshi; Kobayashi, Noriyuki; Hirai, Katsuyuki
Journal of the American Chemical Society, 1995 , vol. 117, # 16 p. 4483 - 4498
反应条件
thionyl chloride; tin(IV) chloride
参考文献
Allelix Neuroscience Inc.
Patent: US6162824 A1, 2000 ;
反应条件
sodium dichromate; acetic acid
参考文献
Kruber; Raeithel
Chemische Berichte, 1954 , vol. 87, p. 1469,1475
反应条件
1.1: Mg / tetrahydrofuran
1.2: 57 percent / tetrahydrofuran / 20 °C
2.1: 10 percent / cesium pivalate / Pd(PCy3)2 / dimethylformamide / 7 h / 110 °C / 760.05 Torr
View Scheme
参考文献
Campo; Larock
Organic letters, 2000 , vol. 2, # 23 p. 3675 - 3677
反应条件
1.1: Mg / tetrahydrofuran
1.2: 57 percent / tetrahydrofuran / 20 °C
2.1: 10 percent / cesium pivalate / Pd(PCy3)2 / dimethylformamide / 7 h / 110 °C / 760.05 Torr
View Scheme
参考文献
Campo; Larock
Organic letters, 2000 , vol. 2, # 23 p. 3675 - 3677
反应条件
2,2,2-trimethylacetic acid in dimethylammonium 2,4-dichlorophenoxyacetate; toluene
T=120°C; 10 h;
参考文献
Liu, Tao-Ping; Liao, Yuan-Xi; Xing, Chun-Hui; Hu, Qiao-Sheng
Organic Letters, 2011 , vol. 13, # 9 p. 2452 - 2455
反应条件
palladium diacetate; potassium carbonate; trifluoroacetic acid; silver(l) oxide
T=140°C; Nazarov Cyclization; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Li, Hu; Zhu, Ru-Yi; Shi, Wen-Juan; He, Ke-Han; Shi, Zhang-Jie
Organic Letters, 2012 , vol. 14, # 18 p. 4850 - 4853,4
反应条件
1: 1.) Mg / 1.) Et2O, 2.) benzene, RT, overnight
2: conc. HCl / ethanol / 4 h
3: 60 percent / 5 N aq. HCl, aq. NaNO2 / 1.) 0 deg C, 2.) reflux, 2.5 h
View Scheme
参考文献
Tomioka, Hideo; Kawasaki, Hiroshi; Kobayashi, Noriyuki; Hirai, Katsuyuki
Journal of the American Chemical Society, 1995 , vol. 117, # 16 p. 4483 - 4498
反应条件
1: 1.) Mg / 1.) Et2O, 2.) benzene, RT, overnight
2: conc. HCl / ethanol / 4 h
3: 60 percent / 5 N aq. HCl, aq. NaNO2 / 1.) 0 deg C, 2.) reflux, 2.5 h
View Scheme
参考文献
Tomioka, Hideo; Kawasaki, Hiroshi; Kobayashi, Noriyuki; Hirai, Katsuyuki
Journal of the American Chemical Society, 1995 , vol. 117, # 16 p. 4483 - 4498
反应条件
1: With palladium diacetate; copper(II) bis(trifluoromethanesulfonate) in 1,4-dioxane
T=90°C; Molecular sieve;
2: With trifluoroacetic acid in 1,4-dioxane
参考文献
Sun, Chang-Liang; Liu, Na; Li, Bi-Jie; Yu, Da-Gang; Wang, Yang; Shi, Zhang-Jie
Organic Letters, 2010 , vol. 12, # 1 p. 184 - 187
