2-(1-苄基-4-哌啶)乙腈合成路线 （共 6 条）
反应条件
1: 74 percent / Mg / methanol / 4 h / Ambient temperature 2: 53 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 4 p. 730 - 741
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With potassium carbonate in tetrahydrofuran
T=20°C; 0.583333 h; Reflux;
2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran
T=70°C; 16 h;
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
Location in patent: Page/Page column 78 ;
WO 2011/104680 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 14 h / 65 °C
2.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux
2.2: 16 h / 70 °C
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
WO 2011/104680 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 14 h / 65 °C
2.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux
2.2: 16 h / 70 °C
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
WO 2011/104680 A1
反应条件
1: iodine; magnesium / methanol
2: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C
View Scheme
参考文献
Universitat Autònoma de Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); National University Corporation Okayama University; Universidad de Alcalá; Esteban, Gerard; Unzeta, Mercedes; Inokuchi, Tsutomu; Marco-Contelles, José Luis; Samadi, Abdelouahid; Iriepa, Isabel; Ojima, Masaki; Li, Wang
Patent: EP2727916 A1, 2014 ;
反应条件
1: With magnesium in methanol
T=5 - 10°C; 4 h;
2: With hydrogenchloride in methanol; water
3: With sodium hydroxide in methanol; water
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
Location in patent: Page/Page column 78 ;
WO 2011/104680 A1
