1-Aza-双环[2.2.2]辛烷-4-羧酸合成路线 (共 9 条)
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
2: 260 - 270 °C / 13 Torr
3: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: methanol / Hydrieren des Reaktionsgemisches an Raney-Nickel
2: SOCl2; benzene
3: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
4: 260 - 270 °C / 13 Torr
5: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: acetone
2: Raney nickel; methanol; triethylamine / 90 °C / 73550.8 Torr / Hydrogenation
3: NH3; methanol
4: SOCl2; benzene
5: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
6: 260 - 270 °C / 13 Torr
7: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: NH3; methanol
2: SOCl2; benzene
3: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
4: 260 - 270 °C / 13 Torr
5: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: Raney nickel; dioxane / 175 - 180 °C / 80905.8 Torr / Hydrogenation
2: methanol / Hydrieren des Reaktionsgemisches an Raney-Nickel
3: SOCl2; benzene
4: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
5: 260 - 270 °C / 13 Torr
6: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: SOCl2; benzene
2: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
3: 260 - 270 °C / 13 Torr
4: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: Raney nickel; methanol; triethylamine / 90 °C / 73550.8 Torr / Hydrogenation
2: NH3; methanol
3: SOCl2; benzene
4: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
5: 260 - 270 °C / 13 Torr
6: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
thionyl chloride
2 h; Heating;
参考文献
MacLeod, Angus M.; Cascieri, Margaret A.; Merchant, Kevin J.; Sadowski, Sharon; Hardwicke, Sarah; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 934 - 941