反应条件
1: 6-fluoro-1H-indole-2-carboxylic acid ethyl ester; methyl 6-fluoroindole-2-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=20°C; 12 h;
参考文献
Burnier, Philippe; Froissant, Jacques; Marabout, Benoit; Marguet, Frank; Puech, Frederic
Patent: US2005/96321 A1, 2005 ;
Location in patent: Page/Page column 5 ;
