2-(2-苯乙基)苯甲腈合成路线 （共 11 条）
反应条件
1: 2-(phenyl)ethyl bromide With magnesium in tetrahydrofuran
2: With zinc(II) chloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=60°C; 0.333333 h;
3: ortho-chloro-benzonitrile With ((Cy2POH)2PdCl)2 in 1-methyl-pyrrolidin-2-one
T=70°C; 20 h; Further stages.;
参考文献
Xu, Hanhui; Ekoue-Kovi, Kekeli; Wolf, Christian
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7638 - 7650
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=760 Torr; Ambient temperature; Yield given;
参考文献
Scholz; Schmidt; Prieschl; Csonga; Scheirer; Weber; Lembachner; Seidl; Werner; Mayer; Baumruker
Journal of medicinal chemistry, 1998 , vol. 41, # 7 p. 1050 - 1059
反应条件
1: 2-methylbenzonitrile With N,N'-dimethyl-N,N'-propyleneurea; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; Metallation; 0.25 h;
2: benzyl bromide in tetrahydrofuran; hexane
T=-78°C; Alkylation; 0.5 h;
参考文献
Bunce, Richard A.; Johnson, Lara B.
Organic Preparations and Procedures International, 1999 , vol. 31, # 4 p. 407 - 412
反应条件
isopropyl alcohol; anhydrous 4,4'-bipyridyl in ammonia
T=-38°C; electrolyses;
参考文献
Chami, Zoubida; Gareil, Monique; Pinson, Jean; Saveant, Jean-Michel; Thiebault, Andre
Tetrahedron Letters, 1988 , vol. 29, # 6 p. 639 - 642
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Ambient temperature
2: H2 / 5percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Scholz; Schmidt; Prieschl; Csonga; Scheirer; Weber; Lembachner; Seidl; Werner; Mayer; Baumruker
Journal of medicinal chemistry, 1998 , vol. 41, # 7 p. 1050 - 1059
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Ambient temperature
2: H2 / 5percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Scholz; Schmidt; Prieschl; Csonga; Scheirer; Weber; Lembachner; Seidl; Werner; Mayer; Baumruker
Journal of medicinal chemistry, 1998 , vol. 41, # 7 p. 1050 - 1059
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
2 h; Heating;
参考文献
Bowman; Bridge; Brookes
Tetrahedron Letters, 2000 , vol. 41, # 46 p. 8989 - 8994
反应条件
phosphorus pentoxide
T=200 - 210°C;
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1880 - 1894
反应条件
T=195°C; im Wasserstoff-Strom;
参考文献
Bergmann
Journal of Organic Chemistry, 1939 , vol. 4, p. 1,9
反应条件
1: aq. NH3
2: P2O5 / 200 - 210 °C
View Scheme
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1880 - 1894
