7-氮杂吲哚-7-氧化物合成路线 （共 49 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane 72 h;
参考文献
Huestis, Malcolm P.; Fagnou, Keith
Organic Letters, 2009 , vol. 11, # 6 p. 1357 - 1360
反应条件
potassium carbonate in water pH=9;
参考文献
AC IMMUNE S.A.; KROTH, Heiko; HAMEL, Cotinica; BENDERITTER, Pascal; FROESTL, Wolfgang; SREENIVASACHARY, Nampally; MUHS, Andreas
Patent: WO2011/128455 A1, 2011 ;
Location in patent: Page/Page column 82 ;
WO 2011/128455 A1
反应条件
3-chloro-benzenecarboperoxoic acid in ethylene glycol dimethyl ether T=20°C; 2 h; Cooling with ice;
参考文献
WO2013/10880 A1, ;
Page/Page column 99 ;
反应条件
potassium carbonate in water pH = 9;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
sodium hydrogencarbonate in methanol; water
参考文献
US6878714 B2, ;
US 6878714 B2
反应条件
water; potassium carbonate in chloroform
参考文献
El-Gamal, Mohammed I.; Jung, Myung-Ho; Oh, Chang-Hyun
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3216 - 3218
反应条件
1: 51 percent / tetrahydrofuran / 1 h / Ambient temperature 2: 100 percent / NaOH / methanol / 24 h / Ambient temperature View Scheme
参考文献
Minakata; Komatsu; Ohshiro
Synthesis, 1992 , # 7 p. 661 - 663
反应条件
[14C]-Tetramethylammonium bromide; trifluoromethanesulfonic anhydride in N,N-dimethyl-formamide T=0 - 20°C; 5 h;
参考文献
Chang, Shaohua; Zhang, Zhang; Zhuang, Xiaoxi; Luo, Jinfeng; Cao, Xianwen; Li, Honglin; Tu, Zhengchao; Lu, Xiaoyun; Ren, Xiaomei; Ding, Ke
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1208 - 1212
反应条件
1: With [14C]-Tetramethylammonium bromide in N,N-dimethyl-formamide; acetonitrile T=0 - 20°C; 2: With sodium hydroxide in water; N,N-dimethyl-formamide; acetonitrile pH=7;
参考文献
Wyeth
Patent: US2009/298820 A1, 2009 ;
Location in patent: Page/Page column 36-37 ;
US 20090298820 A1
反应条件
1: With [14C]-Tetramethylammonium bromide; trifluoromethanesulfonic anhydride in N,N-dimethyl-formamide T=0°C; 12 h; Heating; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=7; 0.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/126675 A1, 2009 ;
Location in patent: Page/Page column 128-129 ;
WO 2009/126675 A1
