3-羟基-5-硝基苯甲酸甲酯合成路线 （共 7 条）
反应条件
Oxonereg;; sodium hydrogencarbonate; sodium hydroxide in water; acetone T=8°C; 0.0833333 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2010/227894 A1, 2010 ;
Location in patent: Page/Page column 73 ;
US 20100227894 A1
反应条件
acetyl chloride 18 h; Ambient temperature;
参考文献
Abraham; Gazze; Kennedy; Mokotoff
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559
反应条件
sulfuric acid; sodium carbonate in methanol; water
反应条件
1: 1.) aq. H2SO4, NaN2, 2.) aq H2SO4 / 2.) reflux, 30 min 2: 82.4 percent / AcCl / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 12 p. 1549 - 1559
反应条件
1: 80 percent / 1.) aq. NH3, 2.) H2S 2: 1.) aq. H2SO4, NaN2, 2.) aq H2SO4 / 2.) reflux, 30 min 3: 82.4 percent / AcCl / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 12 p. 1549 - 1559
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2010/227894 A1, 2010 ;
Location in patent: Page/Page column 73 ;
US 20100227894 A1
反应条件
1: 81 percent / NaH / tetrahydrofuran / 8 h / Heating
2: 86 percent / H2 / 10percent Pd/C / methanol / 18 h / 1810.02 Torr
3: 87 percent / Et3N / tetrahydrofuran / 1.5 h
4: 91 percent / aq. NaOH / methanol / 2 h / 60 °C
View Scheme
参考文献
Abraham; Gazze; Kennedy; Mokotoff
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559
