2-双甲基磺酰-亚甲基丙二酸二乙酯合成路线 （共 5 条）
反应条件
copper(I) bromide in diethyl ether
参考文献
Ittah,Y.; Shahak,I.
Synthesis, 1976 , p. 320 - 321
反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: carbon disulfide in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
3: methyl iodide in N,N-dimethyl-formamide
T=5 - 20°C; 15 h;
参考文献
Wiles, Jason A.; Hashimoto, Akihiro; Thanassi, Jane A.; Cheng, Jijun; Incarvito, Christopher D.; Deshpande, Milind; Pucci, Michael J.; Bradbury, Barton J.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 39 - 42
反应条件
1: carbon disulfide; diethyl malonate With potassium carbonate in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: methyl bromide in N,N-dimethyl-formamide
T=0 - 20°C; 8.25 h;
参考文献
Dong, Ying; Wang, Mang; Liu, Jun; Ma, Wei; Liu, Qun
Chemical Communications, 2011 , vol. 47, # 26 p. 7380 - 7382
反应条件
1: carbon disulfide; diethyl malonate With sodium hydride in benzene
2: methyl halide
参考文献
Musad, Ebraheem Abdu; Rai, K. M. Lokanatha
Synthetic Communications, 2010 , vol. 40, # 23 p. 3569 - 3576
参考文献
Ilford Ltd.
Patent: US2493071 , 1946 ;
