dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; triethylamine; palladium dichloride in 1,4-dioxane T=110°C; 16 h; Inert atmosphere;

tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; thiourea; 1,1,1-tris (diphenylphosphinomethyl)ethane in 1,4-dioxane T=100°C; 18 h; Inert atmosphere;

potassium carbonate; [Pd(C3H5)Cl]2/Tedicyp complex in xylene T=130°C; Suzuki reaction; 20 h;

palladium diacetate; caesium carbonate; tri-cyclo-hexyl-phosphine in o-xylene T=110°C; 20 h;

(IPr)Pd(cinnamyl)(Cl); potassium carbonate; 2-oxo-3,3-dimethyl-butanoic acid in N,N-dimethyl acetamide T=140°C; 16 h;

tri(n-propyl)amine; copper(l) iodide; 1,10-phenanthroline in 1,4-dioxane T=20 - 100°C; Wittig Olefination; 32.0833 h; Inert atmosphere;

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; thiourea; 1,1,1-tris (diphenylphosphinomethyl)ethane / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere View Scheme

dichloro bis(acetonitrile) palladium(II); 1,2-dichloro-ethane; copper dichloride T=80°C; 16 h; Inert atmosphere; Overall yield = 19 percent; Overall yield = 21 mg; regioselective reaction;