1-(3,4-二甲氧基苯基)-1-环己烷甲胺合成路线 (共 2 条)
反应条件
1: 1-(3,4-dimethoxyphenyl)cyclohexanecarbonitrile With lithium aluminium tetrahydride in diethyl ether
T=0 - 20°C; 16 h;
2: 1,4-dichloropentane 16 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/35514 A2, 2005 ;
Location in patent: Page/Page column 115-116 ;
WO 2005/035514 A2
参考文献
Hoffmann-La Roche Inc.
Patent: US5302727 A1, 1994 ;