(2S)-2-羟基-1,5-二甲基酯戊二酸合成路线 (共 3 条)
反应条件
1: 79 percent / Ag2O / ethyl acetate / 48 h / 20 °C 2: 88 percent / LiAlH4 / diethyl ether / 24 °C 3: 86 percent / DMAP; Et3N / CH2Cl2 / 12 h / 20 °C 4: 74 percent / NH2OH*HCl; Et3N / 4 h / Heating 5: MnO2 / CH2Cl2 / 12 h / 0 °C 6: 48 percent / toluene / 24 h / Heating 7: Zn; AcOH / Heating 8: Et3N / CH2Cl2 9: Dess-Martin periodinane; pyridine / CH2Cl2 10: 67 percent / aq. HCl / Heating View Scheme
参考文献
Ashoorzadeh, Amir; Caprio, Vittorio
Synlett, 2005 , # 2 art. no. D32004ST, p. 346 - 348
反应条件
1: 97 percent / BH3*Me2S, NaBH4 / tetrahydrofuran / 0 °C
2: 88 percent / imidazole / dimethylformamide
3: 91 percent / LiAlH4 / tetrahydrofuran / 0 °C
4: 84 percent / SO3*Py, DMSO, Et3N / CH2Cl2
View Scheme
参考文献
Shimizu, Atsushi; Nishiyama, Shigeru
Tetrahedron Letters, 1997 , vol. 38, # 34 p. 6011 - 6014
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: Novozym 435 lipase B from Candida antarctica / 30 °C<br />2: Mucor rouxii yeast-like cells / hexane; H<sub>2</sub>O / 24 h / 28 °C<br /> <br />
参考文献
Rustoy, Eduardo M.; Pereyra, Elba N.; Moreno, Silvia; Baldessari, Alicia Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3763 - 3768