water; alkaline phosphatase T=20°C; pH=7.4; 0.25 h; TRIS buferEnzymatic reaction;

1.1: ZnI2 / benzene / 20 °C 1.2: POCl3; pyridine / benzene / 6 h / Heating 2.1: p-cymene / Pd/C / Heating 3.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C 4.1: Br2; acetic acid / 6 h / 100 °C 4.2: aq. HCl; SnCl2 / 1 h / 100 °C 5.1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C 6.1: 0.085 g / C6H5N*HCl / 2 h / 190 °C View Scheme

1.1: p-cymene / Pd/C / Heating 2.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C 3.1: Br2; acetic acid / 6 h / 100 °C 3.2: aq. HCl; SnCl2 / 1 h / 100 °C 4.1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C 5.1: 0.085 g / C6H5N*HCl / 2 h / 190 °C View Scheme

C6H5N*HCl T=190°C; 2 h;

1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C 2: 0.085 g / C6H5N*HCl / 2 h / 190 °C View Scheme

1.1: Br2; acetic acid / 6 h / 100 °C 1.2: aq. HCl; SnCl2 / 1 h / 100 °C 2.1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C 3.1: 0.085 g / C6H5N*HCl / 2 h / 190 °C View Scheme

1.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C 2.1: Br2; acetic acid / 6 h / 100 °C 2.2: aq. HCl; SnCl2 / 1 h / 100 °C 3.1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C 4.1: 0.085 g / C6H5N*HCl / 2 h / 190 °C View Scheme

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