7-(三氟甲基)-1-苯并噻吩-2-羧酸甲酯合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 2 h;
参考文献
WO2012/153860 A1, ;
Page/Page column 22-23 ;
反应条件
1: 2-mercaptoacetic acid methyl ester; 2-fluoro-3-(trifluoromethyl)benzaldehyde With potassium carbonate in N,N-dimethyl-formamide T=140°C; 2 h; 2: With hydrogenchloride in water 3: methanol With oxalyl dichloride T=80°C; 2 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MUKUMOTO, Fujio; TAMAKI, Hiroaki
Patent: US2014/135214 A1, 2014 ;
Location in patent: Page/Page column 0105-0106 ;
反应条件
1: With lithium hydroxide hydrate; water in methanol T=75°C; 2 h; 2: With hydrogenchloride in water
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MUKUMOTO, Fujio; TAMAKI, Hiroaki; IWAKOSHI, Mitsuhiko; KUSAKA, Shintaro
Patent: WO2012/153861 A1, 2012 ;
Location in patent: Page/Page column 24-25 ;
