6-甲氧基苯并[b]噻吩-2-羧酸甲酯合成路线 （共 3 条）
反应条件
1: With methanol; sodium hydroxide; water T=65°C; 18 h; 2: With hydrogenchloride; water in methanol T=0°C;
参考文献
Branum, Shawn T.; Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher M.; Jetter, Michele C.; Liu, Yi; Ludovici, Donald; Macielag, Mark J.; Matthews, Jay M.; McNally, James J.; Reaney, Laura M.; Russell, Ronald K.; Qin, Ning; Teleha, Christopher; Wells, Kenneth M.; Youells, Scott C.; Youngman, Mark A.
Patent: US2012/190674 A1, 2012 ;
Location in patent: Page/Page column 87 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=100°C; 72 h;
参考文献
Branum, Shawn T.; Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher M.; Jetter, Michele C.; Liu, Yi; Ludovici, Donald; Macielag, Mark J.; Matthews, Jay M.; McNally, James J.; Reaney, Laura M.; Russell, Ronald K.; Qin, Ning; Teleha, Christopher; Wells, Kenneth M.; Youells, Scott C.; Youngman, Mark A.
Patent: US2012/190674 A1, 2012 ;
Location in patent: Page/Page column 87 ;
反应条件
copper in N,N-dimethyl-formamide
T=170°C; Ullmann reaction; 16 h;
参考文献
Mezlova, Marie; Petrickova, Hana; Malon, Petr; Kozmik, Vaclav; Svoboda, Jiri
Collection of Czechoslovak Chemical Communications, 2003 , vol. 68, # 5 p. 1020 - 1038
