反应条件
1: 1) t-BuOK / 1) DMSO, RT, 2) DMSO, 30 min 2: DIBAL / toluene; CH2Cl2 / 0.5 h / -78 °C 3: BF3*Et2O / 2 h / -20 °C 4: imidazole / dimethylformamide / 0.17 h / 40 °C 5: 80percent m-chloroperbenzoic acid / CH2Cl2 / 1) -78 to 0 deg C, 30 min,2) 0 deg C,2 h 6: 1) n-butyllithium, 2) BF3*Et2O / 1) THF, hexane, -78 deg C, 5 min,2) THF, hexane, 10 min, 3) THF, hexane, -30 deg C, 2 h 7: pyridine / 15 h / Ambient temperature 8: 6percent sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature 9: 77 percent / 0.3N hydrochloric acid / acetonitrile / 2 h 10: 1) t-BuOK / 1) THF, 2) THF, 30 min 11: tetrabutylammonium fluoride / tetrahydrofuran / 48 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 15 p. 4989 - 4998
