5-甲氧基苯并呋喃-2-硼酸合成路线 （共 3 条）
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / ethanol / 0.25 h / 140 °C / Microwave irradiation 2: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C 3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 4: boron tribromide / dichloromethane / 0 - 20 °C View Scheme
参考文献
Swahn, Britt-Marie; Sandell, Johan; Pyring, David; Bergh, Margareta; Jeppsson, Fredrik; Jureus, Anders; Neelissen, Jan; Johnstroem, Peter; Schou, Magnus; Svensson, Samuel
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4332 - 4337
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C;
2: With tri-isopropoxy-borane in tetrahydrofuran
参考文献
Swahn, Britt-Marie; Wensbo, David; Sandell, Johan; Sohn, Daniel; Slivo, Can; Pyring, David; Malmstroem, Jonas; Arzel, Erwan; Vallin, Michaela; Bergh, Margareta; Jeppsson, Fredrik; Johnson, Allan E.; Jureus, Anders; Neelissen, Jan; Svensson, Samuel
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1976 - 1980
反应条件
1: 5-methoxybenzo[b]furan With n-butyllithium in tetrahydrofuran
T=-60 - -10°C; 1.25 h; Inert atmosphere;
2: tri-isopropoxy-borane in tetrahydrofuran
T=-60 - 20°C;
3: water With hydrogenchloride in tetrahydrofuran
T=20°C; 1 h;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 63 ;
