3-羧甲基-6-苄基-2,5-二氧代哌嗪合成路线 （共 6 条）
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US4780561 A1, 1988 ;
反应条件
hydrogenchloride; sodium hydroxide in methanol
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US4780561 A1, 1988 ;
反应条件
carbonate buffer (pH 10.1 in water) in acetone
T=25°C; studied in binary aqueous-organic solvent mixtures (organic cosolvents: acetone, acetonitrile, DMSO, dioxane, THF, methanol); second solution condition: 1.0M HCl (pH 0.28); Kinetics;
参考文献
Skwierczynski; Connors
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 12 p. 1690 - 1696
反应条件
water
35 h; var. reaction pH and temp.; Rate constantKinetics;
参考文献
Gaines, Susan M.; Bada, Jeffrey L.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2757 - 2764
反应条件
T=167 - 180°C; aminolysis; Activation energyKineticsThermodynamic data;
参考文献
Leung, Suzanne S.; Grant, David J. W.
Journal of Pharmaceutical Sciences, 1997 , vol. 86, # 1 p. 64 - 71
反应条件
T=186 - 202°C; aminolysis; Activation energyKineticsThermodynamic data;
参考文献
Leung, Suzanne S.; Grant, David J. W.
Journal of Pharmaceutical Sciences, 1997 , vol. 86, # 1 p. 64 - 71
