4-(叔丁基二甲基硅氧)环己酮合成路线 （共 17 条）
反应条件
sodium tetrahydroborate in methanol T=-50 - 20°C;
参考文献
Zhuo, Jincong; Li, Yun-Long; Xu, Meizhong; He, Chunhong; Yao, Wenqing
Patent: US2007/208001 A1, 2007 ;
Location in patent: Page/Page column 50 ;
US 20070208001 A1
反应条件
Na(1+)*HSO4(1-)*SiO2 = NaHSO4*SiO2 2 h;
参考文献
Li, Yun; Hao; Zhang, Qi; Wu, Yikang
Organic Letters, 2009 , vol. 11, # 7 p. 1615 - 1618
反应条件
palladium (II) trifluoroacetate; oxygen; acetic acid; dimethyl sulfoxide T=80°C; P=760.051 Torr; 20 h;
参考文献
Diao, Tianning; Stahl, Shannon S.
Journal of the American Chemical Society, 2011 , vol. 133, # 37 p. 14566 - 14569
反应条件
1: ZnI2 / CH2Cl2 / 5 h / 20 °C
2: 81 percent / aq. HCl / Heating
3: 53 percent / DEAD; Ph3P / tetrahydrofuran
View Scheme
参考文献
Rath, Jean-Philippe; Eipert, Martin; Kinast, Stephan; Maier, Martin E.
Synlett, 2005 , # 2 art. no. G42904ST, p. 314 - 318
反应条件
potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; Esterification; 4 h;
参考文献
Carreno, M. Carmen; Urbano, Antonio; Di Vitta, Claudio
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8320 - 8330
反应条件
1: 4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexanone With sodium hexamethyldisilazane in tetrahydrofuran
T=-20°C;
2: trifluoromethanesulfonic acid anhydride in tetrahydrofuran
T=-20 - 20°C; 12.1667 h;
参考文献
AMGEN INC.
Patent: US2010/160280 A1, 2010 ;
Location in patent: Page/Page column 128-129 ;
反应条件
1: 4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexanone With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
SANOFI; GAO, Zhongli
Patent: WO2011/143150 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/143150 A1
