2-(二甲氧基亚膦酰)-2-丙烯酸甲酯合成路线 （共 7 条）
反应条件
1: formaldehyd With piperidine in methanol
3 h; Heating / reflux;
2: dimethyl methoxycarbonylmethanephosphonate in methanol
18 h; Heating / reflux;
3: With toluene-4-sulfonic acid in toluene
18 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/171015 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080171015 A1
反应条件
1: methanol; formaldehyd With piperidine
3 h; Heating / reflux;
2: dimethyl (carboxymethyl)phosphonate in methanol
T=50°C; 18 h; Heating / reflux;
3: With toluene-4-sulfonic acid in methanol; toluene
Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/275930 A1, 2007 ;
Location in patent: Page/Page column 22 ;
US 20070275930 A1
反应条件
1: formaldehyd With piperidine in methanol
3 h; Heating / reflux;
2: dimethyl (carboxymethyl)phosphonate in methanol
T=50°C; 18 h; Heating / reflux;
3: methanol With toluene-4-sulfonic acid in toluene
18 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/270406 A1, 2007 ;
Location in patent: Page/Page column 28 ;
US 20070270406 A1
反应条件
1: formaldehyd With piperidine in methanol
3 h; Heating / reflux;
2: dimethyl methoxycarbonylmethanephosphonate With methanol
18 h; Heating / reflux;
3: With toluene-4-sulfonic acid in toluene
18 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/270405 A1, 2007 ;
Location in patent: Page/Page column 47 ;
US 20070270405 A1
反应条件
1: With piperidine
Condensation; Addition; 2 h; Heating;
2: With toluene-4-sulfonic acid in toluene
Elimination; 4 h; Heating; Title compound not separated from byproducts;
参考文献
Leonard, John; Hague, Andrew B.; Jones, Martin F.; Ward, Richard A.
Synthesis, 2000 , # 4 p. 507 - 509
反应条件
piperidine
Condensation; Addition; 2 h; Heating; Title compound not separated from byproducts;
参考文献
Leonard, John; Hague, Andrew B.; Jones, Martin F.; Ward, Richard A.
Synthesis, 2000 , # 4 p. 507 - 509
反应条件
triethylamine in toluene
Ring cleavage; Cyclization; 4 h; Heating;
参考文献
Leonard, John; Hague, Andrew B.; Jones, Martin F.; Ward, Richard A.
Synthesis, 2000 , # 4 p. 507 - 509
