1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexanes T=4°C; 1 h; Inert atmosphere; 2: 4-acetyl-butanoic acid in tetrahydrofuran; hexanes T=4 - 20°C; Inert atmosphere;

1: With copper(I) oxide in acetonitrile T=85°C; 20 h; Inert atmosphere; 2: With hydrogenchloride in water T=0°C; Inert atmosphere;

暂无反应条件数据

1: With sodium hydroxide in ethanol; water 3 h; Inert atmosphereReflux; 2: With hydrogenchloride; water Inert atmosphere;

potassium hydroxide in methanol Heating;

1.1: pyridine / dichloromethane / 15.25 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride; potassium iodide / tetrahydrofuran; mineral oil / 0.25 h / 20 - 70 °C / Inert atmosphere 2.2: 20.08 h / 70 °C / Inert atmosphere 3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 40 h / 20 °C 3.2: 0 °C / pH 3 4.1: copper(I) oxide / acetonitrile / 20 h / 85 °C / Inert atmosphere 4.2: 0 °C / Inert atmosphere View Scheme

1.1: sodium hydride; potassium iodide / tetrahydrofuran; mineral oil / 0.25 h / 20 - 70 °C / Inert atmosphere 1.2: 20.08 h / 70 °C / Inert atmosphere 2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 40 h / 20 °C 2.2: 0 °C / pH 3 3.1: copper(I) oxide / acetonitrile / 20 h / 85 °C / Inert atmosphere 3.2: 0 °C / Inert atmosphere View Scheme

1.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 40 h / 20 °C 1.2: 0 °C / pH 3 2.1: copper(I) oxide / acetonitrile / 20 h / 85 °C / Inert atmosphere 2.2: 0 °C / Inert atmosphere View Scheme

in methanol 1.5 h; Irradiation;

1: (i) TsCl, Py, (ii) /BRN= 3587243/, DMSO 2: KOH / methanol / Heating View Scheme