2-溴-3,4-二甲氧基苯甲醛合成路线 （共 37 条）
反应条件
sodium hydride; triphenylphosphine; zinc; NiCl2((PPh3)P)2 in toluene T=90 - 95°C; Ullmann-type coupling reaction; 12 h; Product distribution; Further Variations:Reagentsreaction time;
参考文献
Hong; Hoen; Zhang; Lin
Synlett, 2001 , # 10 p. 1527 - 1530
反应条件
hydrogen bromide; acetic acid
参考文献
Yakugaku Zasshi, , vol. 76, p. 1122,1125
Chem.Abstr., , p. 3505
反应条件
n-butyllithium; nitrobenzene 1.) THF, hexane, -75 deg C, 50 min.; 2.) -75 deg C, 4h, -> room temp.; Yield given. Multistep reaction;
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
反应条件
n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. ((CH3)2CHO)3B, stirredat -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797
反应条件
n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. (CH3O)3B, stirred at -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797
反应条件
n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. ((CH3)2CHO)3B, stirredat -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797
反应条件
n-butyllithium in tetrahydrofuran dissolved aromatic bromide in THF, added n-BuLi dropwise, mixt. stirredat -78°C for 15 min; added freshly distd. (CH3O)3B, stirred at -78°C for 30 min, warmed to room temp., stirred for further 20 min; cooled to 0°C, acidified, extracted with CH2Cl2, dried, evapd. under vac.;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797
反应条件
potassium hydroxide in water
T=50°C; 15 h;
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2356 - 2360
反应条件
sodium hydroxide in dimethyl sulfoxide
0.166667 h;
参考文献
Wiegand; Schafer
Tetrahedron, 1995 , vol. 51, # 18 p. 5341 - 5350
反应条件
potassium carbonate in acetone
T=60 - 70°C; 18 h;
参考文献
Burger, Adrian P. N.; Brandt, Edward V.; Roux, David G.
Phytochemistry (Elsevier), 1983 , vol. 22, # 12 p. 2813 - 2818
