2-溴-3,4-二甲氧基苯甲醛合成路线 （共 37 条）
反应条件
1.1: sulfuric acid / acetic acid / 1 h / 20 °C
1.2: 16 h
2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
2.2: -78 - 20 °C
View Scheme
参考文献
Huleatt, Paul B.; Lau, Jacelyn; Chua, Sheena; Tan, Yun Lei; Duong, Hung Anh; Chai, Christina L.L.
Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1339 - 1342
反应条件
1: 98 percent / NaBH4 / tetrahydrofuran; methanol / 2 h
2: SOCl2 / benzene / 20 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 2-bromo-3,4-dimethoxybenzaldehyde With lithium (3-oxatetramethylene)amide in tetrahydrofuran; hexane
T=-80°C;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-80 - -70°C; 0.666667 h;
3: carbon dioxide in tetrahydrofuran; hexane
1 h;
参考文献
Soriano, Maria Del Pilar C.; Shankaraiah, Nagula; Santos, Leonardo Silva
Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1770 - 1773
反应条件
1: 86 percent / tetrahydrofuran / 0 deg C to rt, 3 h
2: 95 percent / NaBH4 / trifluoroacetic acid / 10 deg C to 15 deg C, rt, overnight
3: 90 percent / nBuLi / tetrahydrofuran / -78 deg C, 70 min, -78 deg C to rt
4: 1.) trifluoroacetic anhydride, 2.) CrO3 / 1.) CH2Cl2, 0 deg C to rt, 2.) aq. AcOH, rt, 3 h
View Scheme
参考文献
Almeida, Wanda P.; Costa, Paulo R.R.
Synthetic Communications, 1996 , vol. 26, # 23 p. 4507 - 4518
反应条件
copper in N,N-dimethyl-formamide
T=170°C;
参考文献
Kobayashi; Mineo; Kihara; Tagashira
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 9 p. 2191 - 2198
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol
rt, 15 min; reflux, 48 h;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8725 - 8728
参考文献
Kobayashi; Mineo; Kihara; Tagashira
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 9 p. 2191 - 2198
