反应条件
1: 1.) lithium bis(trimethyl)silylamide / 1.) THF, a) -78 deg C, 1 h, b) 0 deg C, 2 h, 2.) THF, a) -78 deg C, 30 min, b) RT, 4 h
2: AcOH, H2SO4 / 1 h / 100 °C
3: 48 percent / 48 percent aq. HBr / 15 h / Heating
View Scheme
参考文献
Costantino, Luca; Rastelli, Giulio; Gamberini, Maria Cristina; Vinson, Joe A.; Bose, Pratima; Iannone, Anna; Staffieri, Mariagrazia; Antolini, Luciano; Del Corso, Antonella; Mura, Umberto; Albasini, Albano
Journal of Medicinal Chemistry, 1999 , vol. 42, # 11 p. 1881 - 1893
