9-甲基-9-氮杂双环[3.3.1]壬-3-酮合成路线 (共 24 条)
反应条件
T=50 - 60°C; P=88260.9 Torr; Hydrogenation;
参考文献
Alder; Dortmann
Chemische Berichte, 1953 , vol. 86, p. 1544,1552
反应条件
1: With 1-chloroethyl chlorocarbonate in toluene T=20 - 90°C; 44 h; 2: With methanol 2 h; Reflux;
参考文献
NeuroSearch A/S
Patent: WO2009/98209 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
ammonium acetate; hydrogen; reduced PtO2 1.) ethanol, 4d, 2.) RT, 1 atm.; Multistep reaction;
参考文献
Turconi, Marco; Nicola, Massimo; Quintero, Myrna Gil; Maiocchi, Luciano; Micheletti, Rosella; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2101 - 2108
参考文献
Kaur, Jaswinder; Razdan, Balkishen; Ram, Veerma; Pant, Geeta
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 20, # 3 p. 269 - 274