1-碘-3,5-二甲基-4-甲氧基苯合成路线 （共 9 条）
反应条件
nitric acid; sodium nitrite in acetic acid T=25°C; Rate constant;
参考文献
Butler,A.R.; Sanderson,A.P.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1974 , p. 1784 - 1785
反应条件
sulfuric acid; iodine; periodic acid in acetic acid
T=80 - 85°C; 12 h; Further byproducts given;
参考文献
Panetta, Charles A.; Fang, Zheng; Mattern, Daniell L.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7953 - 7958
反应条件
N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride in acetic acid
8 h; Ambient temperature;
参考文献
Kajigaeshi, Shoji; Kakinami, Takaaki; Moriwaki, Masayuki; Watanabe, Masakazu; Fujisaki, Shizuo; Okamoto, Tsuyoshi
Chemistry Letters, 1988 , # 5 p. 795 - 798
反应条件
sulfuric acid; iodine; periodic acid in acetic acid
T=80 - 85°C; 12 h; Yield given. Further byproducts given. Title compound not separated from byproducts;
参考文献
Panetta, Charles A.; Fang, Zheng; Mattern, Daniell L.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7953 - 7958
反应条件
sulfuric acid; iodine; periodic acid in acetic acid
T=80 - 85°C; 12 h; Further byproducts given;
参考文献
Panetta, Charles A.; Fang, Zheng; Mattern, Daniell L.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7953 - 7958
反应条件
1: With tert.-butyl lithium in diethyl ether; hexane
T=-78°C; 1 h; Inert atmosphere;
2: With iodine in diethyl ether; hexane
T=-78 - 20°C; 2 h; Inert atmosphere;
参考文献
Zhao, Wenjun; Huang, Li; Guan, Yong; Wulff, William D.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3436 - 3441
Angew. Chem., 2014 , vol. 126, # 13 p. 3504 - 3509,6
反应条件
sulfuric acid; sodium nitrite
Erwaermen der Reaktionsloesung mit wss. KI;
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
反应条件
1: ICl; aqueous acetic acid
2: aqueous NaOH; methanol
View Scheme
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
反应条件
methanol; sodium hydroxide
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
